Skip to main content
. 2016 Oct 26;3:43. doi: 10.3389/fcvm.2016.00043

Figure 2.

Figure 2

Ipragliflozin attenuated endothelial dysfunction in STZ-induced diabetic mice. (A,B) Vascular reactivity to Ach or SNP was determined using aortic rings isolated from ipragliflozin- or vehicle-administered STZ-induced diabetic mice and control mice. Ipragliflozin administration for 3 weeks ameliorated endothelium-dependent vasodilation in response to Ach compared with the non-treated diabetic group (A). Vasorelaxation in response to SNP did not differ among the three groups (B). (C) STZ-induced diabetic mice had significantly higher urine 8-OHdG level compared with non-diabetic control mice. Ipragliflozin administration significantly ameliorated it compared with vehicle treatment. n = 10–12 per group. Ctrl, control (non-STZ injected); Ipra, ipragliflozin. *P < 0.05 and ***P < 0.001 vs. STZ group. †P < 0.05 vs. Ctrl group.