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. 2016 Oct 26;7:401. doi: 10.3389/fphar.2016.00401

FIGURE 4.

FIGURE 4

GA normalizes Aβ-mediated change in excitatory neurotransmission. (A) Reduction in amplitude and frequency of Spontaneous excitatory post-synaptic currents (sEPSC) following Aβ perfusion. On the left, representative traces are shown; on the right, histograms show the effect of Aβ on amplitude and frequency of sEPSC (as % of baseline). (B) GA prevented Aβ-triggered impairment of sEPSC. On the left, traces of sEPSC are shown. On the right, histograms show effect of GA+Aβ on amplitude and frequency of sEPSC (as % of baseline). (C) GA alone did not alter sEPSC amplitude and frequency. On the left, representative traces in baseline conditions and following perfusion of GA are shown. On the right, histograms show effect of GA on amplitude and frequency of sEPSC (as % of baseline). ∗p < 0.05.