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Circulating IGFI levels parallel breast cancer risk. Circulating IGFI levels are lower in parous women compared to nulliparous women (black line). A FFTB at an early age (red line) reduces IGFI sooner, foregoing the excess circulating IGFI that women who become pregnant for the first time later encounter (green line). This parallels the data on breast cancer risk, with women who undergo a late FFTB displaying an increased breast cancer risk compared to those who undergo an early FFTB.
