Figure 2.

Established trends associated with the protective effect of pregnancy. Age at FFTB is positively correlated with breast cancer risk. Women who experience an early parity benefit from a long-term protection against breast cancer compared to nulliparous women. Interestingly, higher levels of circulating IGFI are also positively associated with breast cancer risk and parous women display lower circulating IGFI levels. Although less firmly established, preeclampsia may be associated with a lower breast cancer risk as well as circulating IGFI levels.