Table 2.

Differences in functional connectivity among PD subgroups and normal subjects.

Seed area	P-value1	Size	Connected location	T	MNI coordinate (x, y, z)
HC group > PD-MCI group
Left anterior medial prefrontal
Cluster 1	0.000	222	Left middle frontal	5.98	-36	12	51
Cluster 2	0.000	210	Right precentral	4.77	54	9	39
Cluster 3	0.004	141	Right insula	5.23	33	30	0
Cluster 4	0.011	111	Left insula	3.86	-45	-3	0
Cluster 5	0.049	77	Left middle frontal	4.25	-60	9	9
Left dorsal medial prefrontal
Cluster 1	0.004	133	Right precentral	4.71	54	9	39
Cluster 2	0.007	120	Left middle frontal	4.88	-39	9	54
Left ventral medial prefrontal
Cluster 1	0.003	141	Right precentral	4.00	54	9	39
Cluster 2	0.014	105	Left inferior parietal	3.90	-33	-48	51
Left superior frontal
Cluster 1	0.000	797	Right precentral	5.19	51	6	36
Cluster 2	0.000	350	Right inferior parietal	4.65	33	-42	54
Cluster 3	0.000	240	Left insula	4.97	-39	-6	-21
Cluster 4	0.000	196	Left precuneus	4.52	-15	-42	60
Cluster 5	0.007	114	Right superior temporal	4.88	57	-24	3
Cluster 6	0.012	100	Left superior temporal	4.63	-63	-48	24
Posterior cingulate cortex
Cluster 1	0.000	236	Right precentral	5.58	54	9	36
			Right middle frontal	4.42	42	0	60
Cluster 2	0.006	121	Left precuneus	4.70	-9	-45	57
Cluster 3	0.006	119	Left insula	3.83	-45	0	0
Left anterior temporal
Cluster 1	0.005	135	Right middle temporal	4.58	54	-30	-6
Cluster 2	0.016	104	Left middle temporal	5.17	-63	-42	-9
Right anterior temporal
Cluster 1	0.013	109	Left middle temporal	5.73	-66	-48	-9
PD-CU group > PD-MCI group
Left anterior medial prefrontal
	0.043	80	Left middle frontal	4.93	-39	9	51
Right anterior temporal
	0.032	87	Left middle temporal	5.62	-63	-42	-9

¹P-value was corrected for multiple comparisons by family-wise error (FWE) correction. MNI, Montreal Neurological Institute.