Table 1.

Natural ERβ ligands and melanoma.

Compound	Cellular model	Effects	Reference
Genistein	Human melanoma cells	Suppression of the growth and the metastatic potential	(158–162, 164, 165)
	Murine B16 melanoma xenografts	Decrease of tumor-associated angiogenesis
Liquiritigenin	Murine B16-F10 melanoma cells and xenografts	Enhancement of antiproliferative and antimetastatic effects of chemotherapy	(142, 166–168)
Apigenin	Human A375 melanoma cells	Proapoptotic and antimetastatic effects	(155, 179–187)
	Murine B16-BL6 melanoma cells
Silymarin	Human A375-S2 melanoma cells	Chemopreventive, antitumor, and antimetastatic activity	(200–203)