Table 1.

Overview of the selected papers

Author	Comparators	Perspective	Model structure	Analysis type	Time horizon (base case analysis)	Primary outcome	Target population	Source of effectiveness data	Source of economic data and price year	Sensitivity analysis
Fox et al. [11]	CRT-D vs OPT CRT-P vs OPT CRT-D vs CRT-P	Payer (United Kingdom, NHS)	Markov model	CEA and CUA	Lifetime horizon	Life years QALYs	HF patients with LVSD (EF < 35 %) NYHA class III or IV and QRS interval > 120 ms	CARE-HF [2] (CRT-P vs OPT)	UK NHS, literature and expert opinion (2006)	Univariate sensitivity on key variables: probabilistic sensitivity analysis
Yao et al. [12]	CRT-D vs OPT CRT-P vs OPT CRT-D vs CRT-P	Payer (UK NHS)	Markov model	CEA and CUA	Lifetime horizon	Life years QALYs	HF patients with LVSD (EF < 35 %) NYHA class II, III or IV LVEF of 30 mm (indexed to height), QRS interval > 120 ms	CARE-HF [2] (CRT-P vs OPT)	UK NHS, 2005	Univariate sensitivity on all variables: probabilistic sensitivity analysis
Aidelsburger et al. [13]	CRT-D vs OPT	Payer (German HCS)	Decision tree and Markov model	CEA and CUA	2 years	Life years QALYs and hospitalisations	HF patients with NYHA class III or IV	COMPANION [1] (CRT-P vs CRT-D)	German HCS, 2005	Univariate sensitivity on key variables: probabilistic sensitivity analysis not reported
Bond et al. [14]	CRT-D vs OPT CRT-D vs CRT-P	Payer (United Kingdom, NHS)	Markov model	CUA	Lifetime horizon	QALYs	HF patients with LVSD (EF < 35 %) NYHA class III or IV and QRS interval > 120 ms	CARE-HF [2]		Univariate sensitivity on key variables: probabilistic sensitivity analysis
Callejo et al. [15]	OPT vs CRT-P vs CRT-D	Payer (Spanish, PHCS)	Decision tree and Markov model	CEA and CUA	Lifetime horizon	Life years QALYs	HF patients with NYHA class II, III or IV and prolonged QRS	CARE-HF [2] (CRT-P vs OPT)	Spanish HCS, 2009	Univariate sensitivity on all variables: probabilistic sensitivity analysis
Bertoldi et al. [16]	CRT-D vs OPT CRT-P vs OPT ICD vs OPT CRT-D vs CRT-P CRT-D vs ICD	Payer (Brazilian HCS)	Decision tree and Markov model	CEA and CUA	20 years	Life years QALYs	HF patients with LVSD (EF < 35 %) NYHA class II, III or IV prolonged QRS	Meta-analysis	Brazilian HCS, 2011	Univariate sensitivity on all variables: probabilistic sensitivity analysis
Neyt et al. [17]	CRT-P vs OPT CRT-D vs CRT-P	Payer (Belgian HCS)	Decision tree and Markov model	CEA and CUA	Lifetime horizon	Life years QALYs	HF patients with LVSD (EF ≤ 35 %) NYHA class III or IV prolonged QRS	COMPANION [1] (CRT-P vs CRT-D)	Belgian HCS, 2010	No univariate sensitivity results reported; Scenario analysis on mortalities, hospitalisations, discount rates and device service life: probabilistic sensitivity analysis
Colquitt et al. [18]	CRT-D vs OPT CRT-P vs OPT CRT-D vs CRT-P CRT-D vs ICD	Payer (United Kingdom, NHS)	Markov model	CEA and CUA	Lifetime horizon	Life years QALYs	HF patients with reduced LVSD and cardiac dyssynchrony despite OPT Patients at increased risk of SCD as a result of ventricular arrhythmias despite receiving OPT	CARE-HF [2] (CRT-P vs OPT); MADIT-CRT [21] (CRT-D vs ICD); RAFT (CRT-D vs ICD)	UK NHS, literature and expert opinion (2013)	Univariate sensitivity on key variables: probabilistic sensitivity analysis

CRT-P implantable cardiac resynchronization therapy device with a biventricular pacemaker, CRT-D cardiac resynchronization therapy device with the addition of an implantable cardioverter-defibrillator, OPT optimal drug therapy, ICD implantable cardioverter-defibrillator, NHS National Health Service, HCS health care system, PHCS public health care system, CEA cost-effectiveness analysis, CUA cost utility analysis, QALYs quality of life adjusted life years, HF heart failure, LVSD left ventricular systolic dysfunction, NYHA New York Heart Association functional classification, SCD sudden cardiac death, LVEF left ventricular ejection fraction