Table 4.
Anterior and posterior pituitary hormone deficiencies following treatment for paediatric CD
| Pt no. | CD Therapies | Puberty features | Pubertal induction | Additional long-term pituitary deficiencies | |||||
|---|---|---|---|---|---|---|---|---|---|
| Gonadotrophin | AVP | TSH | ACTH | PRL | Other features | ||||
| 1 | 2 TSS + BA, RT | Slow progression, late menarche at 16.0 years and poor breast development. | + (Oral oestrogen for 0.6 years) | + (HRT since aged 20 years) | – | – | – | – | Breast Augmentation aged 17 years |
| 2 | TSS + RT | no | – | – | – | – | – | ||
| 3 | TSS + RT | no | – | – | – | – | – | – | |
| 4 | TSS + RT | – | – | – | – | – | – | – | |
| 5 | TSS + RT | Slow progression | + (Testosterone for 2.3 years) | – | – | – | – | – | |
| 6 | TSS + RT, BA | Slow progression | – | – | – | – | – | ||
| 7 | 2TSS + RT | Slow progression | – | – | – | – | – | – | Poor semen quality aged 17 years |
| 8 | TSS | Delayed and slow progression | + (Testosterone for 1.2 years) | – | – | + | + | + | |
| 9 | TSS | – | – | – | – | – | – | PCOS 3 children | |
| 10 | TSS | – | – | – | – | – | – | HRT aged 37 years 3 children | |
| 11 | TSS | Late menarche (17.6 years) | – | – | – | – | – | – | Low libido 1 child |
| 12 | 2TSS | Delayed onset | + (Testosterone for 0.3 years) | – | – | – | – | – | |
| 13 | TSS | – | – | – | – | – | – | – | |
| 14 | TSS | Pubertal arrest | + Testosterone since aged 16years | + | – | – | – | ||
| 15 | TSS + RT | – | – | + | + | – | – | ||
| 16 | TSS | – | – | – | – | – | – | ||
| 17 | TSS | – | – | – | – | – | – | ||
| 18 | TSS | – | – | – | – | – | – | High (737, rr 0–496) | |
| 19 | TSS | – | – | – | – | – | – | ||
| 20 | TSS | – | – | – | – | – | – | – | |
| 21 | TSS (diffuse tumour) | HH | + (HCG, FSH) | + (Testogel) | + | + | + | + | Normal semen analysis |
HH hypogonadotropic hypogonadism, + deficiency present, - deficiency absent, AVP vasopressin, TSH thyroid stimulating hormone deficiency, ACTH adrenocorticotropin deficiency, PRL prolactin deficiency