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. 2016 Oct 26;7:394. doi: 10.3389/fphar.2016.00394

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Copyright © 2016 Bi, Zhang, Guo, Bi, Liu, Zou and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expressions of ZO-1, claudin-5 and AQP-4 proteins analyzed by Western blot. High expression levels of ZO-1 and claudin-5 proteins were observed in rat brain tissue in NC group. CO poisoning can markedly decrease the expressions of ZO-1 and claudin-5 proteins both in CO group and NBP+CO group at early stage after exposure to CO. By contrast, NBP administration can significantly increase the levels of both ZO-1 and claudin-5 target proteins compared with those in CO group at the same time (n = 4, P < 0.05). (A) The expressions of ZO-1, claudin-5, AQP-4 and β-actin proteins by Western Blot assay. Lane 1: NC group; Lane 2: day 1 in CO group; Lane 3: day 3 in CO group; Lane 4: day 7 in CO group; Lane 5: day 1 in NBP+CO group; Lane 6: day 3 in NBP+CO group; Lane 7: day 7 in NBP+CO group. (B) The relative A values of ZO-1 protein; (C) The relative A values of claudin-5 protein; (D) The relative A values of AQP-4 protein. ^∗Compared with NC group, P < 0.05; ^# compared with CO group at the same time point, P < 0.05 (F = 11.989∼33.472).