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. 2016 Oct 26;7:394. doi: 10.3389/fphar.2016.00394

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Copyright © 2016 Bi, Zhang, Guo, Bi, Liu, Zou and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The OD value alterations of AQP-4 expression in NC, CO, and NBP+CO groups. A small amount of AQP-4 positive cells scattered in brain tissue in normal rats. After exposure to CO, AQP-4 expression was temporarily elevated and then gradually decreased. NBP treatment caused a slightly higher expression of AQP-4 protein compared to that in CO group, whereas it lacked a statistically significant difference between the two groups (n = 4, P > 0.05). (A) The expressions of AQP-4 positive cells in each group; (B) The OD value alterations of AQP-4 positive cells in different groups (n = 4). ^∗Compared with NC group (n = 4, P < 0.05 (F = 10.621∼56.349). Scale bar = 30 μm.