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. 2016 Oct 27;7:13171. doi: 10.1038/ncomms13171

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Copyright © 2016, The Author(s)

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Intestinal crypts loose stem cells and the proliferative capacity in response to HSP60 loss. WNT-related factors are produced by HSP60-deficient IEC including Paneth cells to compensate diminished proliferation. This epithelial microenvironment causes HSP60-positive escaper stem cells to hyperproliferate and form HSP60-positive crypt nodules, finally leading to tissue reconstitution. In contrast, HSP60 deficiency in Lgr5-positive stem cells causes transient loss of stem cells without alterations in tissue morphology.