Table 1.

Plasma parameters.

	4 weeks		12 weeks		24 weeks
	Control	Fructose	Control	Fructose	Control	Fructose
Plasma glucose(mg/dL)	70 ± 2.4	79 ± 3.6	79 ± 1.6	84 ± 1.9	88 ± 1.3	76 ± 3.0
Plasma insulin (µU/mL)	12 ± 2.0	13 ± 4.0	14 ± 1.4	23 ± 2.4∗	17 ± 3.0	76 ± 19∗
AUC-glucose (mg/dL·min)	188 ± 4.6	203 ± 4.3∗	219 ± 6.6	228 ± 6.6	237 ± 9.5	220 ± 5.7
HOMA-IR	2 ± 0.34	3 ± 0.85	3 ± 0.31	5 ± 0.5∗	4 ± 0.6	18 ± 4.0∗
Plasma TG (mg/dL)	42 ± 4.0	47.3 ± 5.0	37 ± 2.4	52 ± 6.0∗	40 ± 1.9	54 ± 4.1∗
Cholesterol (mg/dL)	82 ± 4.0	82 ± 6.1	72 ± 2.2	89 ± 6.4∗	77 ± 3.08	79 ± 4.0
HDL (mg/dL)	67 ± 6.6	67 ± 4.1	56 ± 2.5	67 ± 5.2	68 ± 2.92	69 ± 3.0
2 × 3 ANOVA	Diet	Time	Diet × Time
Plasma insulin (µU/mL)	S	S	S
HOMA-IR	S	S	S
Plasma triglycerides	S	NS	NS

Values are in mean ± SE of 8 animals from each group at three time points. “∗” indicates statistical significance (p ≤ 0.05) of control and fructose-fed groups at each time point analyzed by Student's t-test. Statistical significance of diet, time, and diet ∗ time on individual parameters is also analyzed by two-way ANOVA. “S” indicates “significant” (p ≤ 0.05); “NS” indicates “not significant.”