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. Author manuscript; available in PMC: 2016 Oct 26.
Published in final edited form as: Curr Opin Immunol. 2014 Oct 14;31:51–57. doi: 10.1016/j.coi.2014.09.007

Figure 1.

Figure 1

Shown is a flowchart outlining the steps to identify relevant triggers of autoimmunity. Analyzing the intersection between SNPs associated with immune-mediated diseases and the genetics of infectious diseases and other endophenotypes helps us to prioritize microbial and environmental triggers. These triggers can then be used as stimuli to activate immune cells to obtain transcriptional responses by RNA sequencing. Cis- and trans-eQTL mapping can then identify both the causal genes and pathways. This information will yield insight into disease mechanisms and in turn inform the choice of relevant therapeutic targets.