Table 2.
Summary of enrichment analysis for the top 1494 differentially expressed genes between groups I, II (SVZ+) versus III, IV (SVZ–) (p < 0.05)
| MetaCoreTM process network | Upregulated in SVZ+ (n = 771) | Downregulated in SVZ+ (n = 723) |
|---|---|---|
| Term | p value (n upregulated/n total) | p value (n downregulated/n total) |
| Blood vessel morphogenesis | 0.669 (4/228) | 1.55E-04 (16/228) |
| Regulation of epithelial-to-mesenchymal transition | 0.943 (2/226) | 4.57E-04 (15/226) |
| Leukocyte chemotaxis | 0.985 (1/205) | 5.32E-04 (14/205) |
| Chromatin modification | 9.61E-04 (9/128) | 0.392 (4/128) |
| T cell receptor signaling | 0.971 (1/174) | 1.22E-03 (12/174) |
| Cytoskeleton - actin filaments | 0.465 (4/176) | 1.35E-03 (12/176) |
| Notch signaling | 0.507 (5/236) |
2.08E-03 (14/236)
0.480 (4/144) |
| Skeletal muscle development | 2.19E-03 (9/144) | |
| Cell cycle G1/S | 0.407 (4/163) | 2.31E-03 (11/163) |
| Inflammation - IL-2 signaling | 0.878 (1/104) | 4.11E-03 (8/104) |
The top 10 enrichments according to p value are depicted (in bold: p < 0.01). In addition, the total number of genes per process network (n total) as well as the intersect with significantly up- or downregulated genes are displayed (n upregulated and n downregulated)