Table 3.
Summary of enrichment analysis for the top 1573 differentially expressed genes between groups II and III (p < 0.05)
| MetaCoreTM process network | Upregulated in group II (n = 957) | Downregulated in group II (n = 616) |
|---|---|---|
| Term | p value (n upregulated/n total) | p value (n downregulated/n total) |
| Blood vessel morphogenesis | 0.058 (10/228) | 2.14E-07 (20/228) |
| Muscle contraction | 1.22E-03 (12/173) | 0.411 (7/173) |
| Male sex differentiation | 0.087 (10/246) | 1.50E-03 (14/246) |
| Transmission of nerve impulse | 2.36E-03 (13/212) | 0.360 (6/212) |
| Neurogenesis | 2.95E-03 (12/192) | 0.452 (5/192) |
| Chemotaxis | 0.669 (3/137) | 4.13E-03 (9/137) |
| Anti-apoptosis via PI3K/Akt | 0.982 (2/233) | 7.16E-03 (12/233) |
| Leukocyte chemotaxis | 0.891 (3/205) | 7.36E-03 (11/205) |
| Neurohormone signaling | 0.273 (7/211) | 9.06E-03 (11/211) |
| Inflammation - IL-2 signaling | 0.482 (3/104) | 9.73E-03 (7/104) |
The top 10 enrichments according to p value are depicted (in bold: p < 0.01). In addition, the total number of genes per process network (n total) as well as the intersect with significantly up- or downregulated genes are displayed (n upregulated and n downregulated)
PI3K phosphatidylinositide 3-kinase, Akt protein kinase B