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. 2016 Oct 26;9:46. doi: 10.1186/s13072-016-0086-0

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Tumor hypoxia increases trimethylation at H3K4 and H3K27. Representative images of whole tumor parallel sections stained for pimonidazole (hypoxia marker, red) and CD31 (PECAM-1; endothelial cell surface marker, green; upper left), H3K27me3 (red) and CD31 (green; upper right), H3K4me3 (red) and CD31 (green; lower left); scale bar represents 1 mm. The color-merged image (lower right) shows pimonidazole (green) and H3K27me3 (red). Captions show enlargements of the indicated areas; scale bar represents 100 µm