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. 2016 Oct 26;16:824. doi: 10.1186/s12885-016-2850-8

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effect of ARHI Induction and Glutaminase Inhibition on Cellular Energetics. The intracellular NAD+/NADH a and ATP/ADP c was determined in for both SKOv3 (parental) and SKOv3-ARHI cells at 12, 24, and 48 h following treatment with Dox (See Methods for additional details). Both ratios were normalized to the values obtained in the Dox- control samples. The same measurements were made for SKOv3-ARHI cells following treatment with Dox, BPTES (1 μM), or both in combination for 48 h (b and d). Seven replicate samples were used for each condition to calculate the mean and standard deviation and statistical significance was determined by two-tailed t-test in GraphPad (*, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001)