Fig. 2.

Progressive time course effect of daily administration of WLR on the nociceptive behavior of animals subjected to oxaliplatin-induced neurotoxicity. To induce OXIPN, animals received 5 mg/kg of oxaliplatin once per week for 2 weeks (total accumulated dose of 10 mg/kg). One week after the final oxaliplatin injection, WLR or amifostine was administered to the animals for 4 weeks as per dosing schedule. At regular time points, a mechanical stimulus was applied on the plantar surface of the right hind paw of the animals using a von Frey monofilament with a 0.4 g bending force, and the response rates were scored. The data represent the combined results of the oxaliplatin plus vehicle (0.5 % CMC, open circles, n = 8), plus WLR (250 mg/kg, closed triangles, n = 8), or plus amifostine (100 mg/kg, open triangles, n = 10) mice. Only the vehicle (0.9 % saline and 0.5 % CMC)-treated mice (closed circles, n = 8) were also included in parallel as a saline control group. *p < 0.05, **p < 0.01, ***p < 0.001 vs. saline-treated control group