Fig. 6.

Effects of WLR on normal cell proliferation and on oxaliplatin-mediated cytotoxicity in cancer cells. a Human normal HFFn cells were subjected to increasing doses of WLR for 48 h, and then, cell viability was determined as described earlier. Relative viability was determined by comparison with the vehicle (PBS) treatment. b The effect of WLR on oxaliplatin-mediated cytotoxicity was evaluated in HCT116 human colorectal cancer cells and A549 human lung cancer cells. Both cells were subjected to a combination of increasing doses of oxaliplatin (0–100 μg/mL) and WLR (PBS, 10, 30, 100 μg/mL) for 48 h, and then, cell viability was determined. The data represent the combined results of n = 3 experiments