Table 1.
Patient demographics [Mean ± SD]
| No treatment | 0.033 mg/kg/day | 0.067 mg/kg/day | ||||
|---|---|---|---|---|---|---|
| n | n | n | ||||
| Gender | 15 | 31 | 34 | |||
| Male, % | 46.7 | 7 | 64.5 | 20 | 58.8 | 20 |
| Female, % | 53.3 | 8 | 35.5 | 11 | 41.2 | 14 |
| Chronological age, years | 5.32 ± 1.38 | 15 | 5.34 ± 1.46 | 31 | 5.27 ± 1.15 | 34 |
| Height, cm | 94.6 ± 8.6 | 15 | 95.9 ± 8.4 | 31 | 94.9 ± 7.3 | 34 |
| Height SDS | -2.92 ± 0.53 | 15 | -2.95 ± 0.64 | 31 | -2.90 ± 0.67 | 34 |
| BMI | 14.07 ± 1.40 | 15 | 14.42 ± 1.26 | 31 | 14.16 ± 1.24 | 34 |
| IGF-I, ng/mL | 115.39 ± 51.01 | 15 | 117.25 ± 49.13 | 31 | 118.20 ± 49.10 | 34 |
| IGF-I SDS | -1.03 ± 1.50 | 15 | -0.75 ± 1.06 | 31 | -0.63 ± 1.21 | 34 |
| Insulin, μU/mL | 2.6 ± 1.7 | 10 | 3.6 ± 2.1 | 26 | 3.2 ± 1.9 | 28 |
| Glucose, mg/dL | 79.8 ± 6.3 | 15 | 82.4 ± 10.4 | 31 | 78.2 ± 11.5 | 34 |
| HbA1c (NGSP), % | 5.08 ± 0.32 | 15 | 5.10 ± 0.29 | 31 | 5.00 ± 0.19 | 34 |
| TC, mg/dL | 173.5 ± 24.2 | 15 | 166.9 ± 29.8 | 31 | 181.4 ± 24.2 | 34 |
| LDL-C, mg/dL | 96.7 ± 18.9 | 15 | 94.8 ± 26.2 | 31 | 104.7 ± 25.0 | 34 |
| HDL-C, mg/dL | 60.4 ± 15.9 | 15 | 56.9 ± 9.6 | 31 | 61.9 ± 12.0 | 34 |
SD standard deviation, SDS standard deviation score, BMI body mass index, IGF-I insulin-like growth factor-1, HbA 1c glycated hemoglobin A1c, NGSP National Glycohemoglobin Standardization Program, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol