Table 1.
Effects of co-administration of BST extract with MDZ on the pharmacokinetic parameters of MDZ and 1ʹ-OH-MDZ (n=3)
| Parameters | BST extract (g/kg) | Oral administration of MDZ |
Intraperitoneal administration of MDZ |
||||||
|---|---|---|---|---|---|---|---|---|---|
| AUC (mg-min/mL) | Cmax (mg/mL) | Half-life (min) | Tmax (min) | AUC (mg-min/mL) | Cmax (mg/mL) | Half-life (min) | Tmax (min) | ||
| MDZ | 0.0 | 45.7±2.9 | 0.7±0.1 | 167.3±116.8 | 5.0±0.0 | 234.5±9.5 | 4.5±0.1 | 23.1±1.5 | 11.7±1.7 |
| 0.5 | 33.9±6.5 | 0.7±0.1 | 59.3±15.3 | 8.3±3.3 | 220.1±26.2 | 4.5±0.5 | 25.0±3.1 | 10.0±0.0 | |
| 1.0 | 16.9±4.1** | 0.3±0.1 | 79.1±1.2 | 26.7±16.9 | 197.9±7.8 | 3.9±0.2 | 23.1±0.8 | 9.0±1.3 | |
| 1'-OH MDZ | 0.0 | 3540.8±312.7 | 43.1±8.5 | 55.3±0.0 | 50.0±10.0 | 18.9±0.8 | 0.2±0.01 | 159.8±11.2 | 20.0±5.0 |
| 0.5 | 3189.7±907.0 | 42.9±12.6 | 71.8±12.3 | 16.7±7.3 | 18.2±0.3 | 0.1±0.01 | 166.0±6.1 | 13.8±1.3 | |
| 1.0 | 1901.0±194.2* | 21.4±2.5 | 101.1±1.7 | 31.7±15.9 | 18.2±0.4 | 0.1±0.0 | 169.0±11.3 | 21.0±3.8 | |
Data are presents as mean±standard errors.
BST, Banha-sasim-tang; MDZ, midazolam; 1ʹ-OH-MDZ, 1ʹ-hydroxymidazolam; AUC, area under the plasma concentration-time curve; Cmax, maximum plasma concentration; Tmax, maximum plasma concentration
*
p<0.05
**
p<0.01 compared to the vehicle-treated group.