Table 1.
Chemotherapy regimens
| Regimen | Drug | Dose (mg/m2/day) | Schedule | Total dose (mg/m2) |
|---|---|---|---|---|
| Induction regimen | ||||
| CECVa) | Cisplatin | 90 | Day 0 | 90 |
| Etoposide | 75 | Days 0-2 | 225 | |
| Cyclophosphamide | 1,500 | Days 1 and 2 | 3,000 | |
| Vincristine | 1.5 | Days 0 and 7 | 3.0 | |
| CEIVa) | Carboplatin | 300 | Days 0 and 1 | 600 |
| Etoposide | 75 | Days 0-4 | 375 | |
| Ifosfamide | 1,500 | Days 0-4 | 7,500 | |
| Vincristine | 1.5 | Days 0 and 7 | 3.0 | |
| HDCT regimen | ||||
| First: CTE | Carboplatin | 500 | Days -8, -7, -6 | 1,500 |
| Thiotepa | 300 | Days -5, -4, -3 | 900 | |
| Etoposide | 250 | Days -5, -4, -3 | 750 | |
| Second: CM | Cyclophosphamide | 1,500 | Days -8, -7, -6, -5 | 6,000 |
| Melphalan | 60 | Days -4, -3, -2 | 180 |
CECV, carboplatin+etoposide+cyclophosphamide+vincristine; CEIV, carboplatin+etoposide+ifosfamide+vincristine; HDCT, high-dose chemotherapy; CTE, carboplatin+thiotepa+etoposide; CM, cyclophosphamide+melphalan.
a)
Dose was determined based on body weight in children under 3 years of age.