Table 4.
Grade 3/4 toxicity profile of tandem HDCT/auto-SCT
| Parameter | First HDCT/auto-SCT (n=10) | Second HDCT/auto-SCT (n=8) | p-value |
|---|---|---|---|
| Hematologic toxicity | |||
| CD34+ cells (×106/kg) | 10.3 (1.7-47.5) | 14.0 (1.3-40.2) | 0.633 |
| Daysa) to reach ANC 500/mm3 | 9 (8-11) | 9.5 (8-11) | 0.360 |
| Daysb) to reach PLT count 20,000/mm3 | 18 (16-52) | 20 (16-64) | 0.963 |
| Days of BT ≥ 38.0°C | 4.5 (1-6) | 3 (0-5) | 0.360 |
| Positive blood culture (No. of patients) | 4 | 1 | 0.314 |
| Non-hematologic toxicity (No. of patients) | |||
| Stomatitis | 7 | 1 | 0.025 |
| Vomiting | 1 | 0 | 0.556 |
| Diarrhea | 3 | 0 | 0.216 |
| Elevation of liver enzymes | 7 | 0 | 0.004 |
| Hyperbilirubinemia | 1 | 0 | 0.556 |
| Renal insufficiency | 0 | 0 | > 0.999 |
| Hypokalemia | 5 | 1 | 0.036 |
| Hyperkalemia | 0 | 0 | > 0.999 |
| Hyponatremia | 2 | 1 | 0.588 |
| Hypernatremia | 0 | 0 | > 0.999 |
| Hepatic VOD | 1 | 1 | 0.706 |
| Myocarditis | 0 | 0 | > 0.999 |
| Seizure | 2 | 0 | 0.477 |
| Treatment-related mortality | 0 | 0 | > 0.999 |
Values are presented as median (range) or number. HDCT/auto-SCT, high-dose chemotherapy and autologous stem cell transplantation; ANC, absolute neutrophil count; PLT, platelet; BT, body temperature; VOD, veno-occlusive disease.
a)
The first of 3 consecutive days that ANC exceeded 500/mm3,
b)
The first of 7 consecutive days that PLT count exceeded 20,000/mm3 without transfusion.