Table 4.
Parameter | First HDCT/auto-SCT (n=10) | Second HDCT/auto-SCT (n=8) | p-value |
---|---|---|---|
Hematologic toxicity | |||
CD34+ cells (×106/kg) | 10.3 (1.7-47.5) | 14.0 (1.3-40.2) | 0.633 |
Daysa) to reach ANC 500/mm3 | 9 (8-11) | 9.5 (8-11) | 0.360 |
Daysb) to reach PLT count 20,000/mm3 | 18 (16-52) | 20 (16-64) | 0.963 |
Days of BT ≥ 38.0°C | 4.5 (1-6) | 3 (0-5) | 0.360 |
Positive blood culture (No. of patients) | 4 | 1 | 0.314 |
Non-hematologic toxicity (No. of patients) | |||
Stomatitis | 7 | 1 | 0.025 |
Vomiting | 1 | 0 | 0.556 |
Diarrhea | 3 | 0 | 0.216 |
Elevation of liver enzymes | 7 | 0 | 0.004 |
Hyperbilirubinemia | 1 | 0 | 0.556 |
Renal insufficiency | 0 | 0 | > 0.999 |
Hypokalemia | 5 | 1 | 0.036 |
Hyperkalemia | 0 | 0 | > 0.999 |
Hyponatremia | 2 | 1 | 0.588 |
Hypernatremia | 0 | 0 | > 0.999 |
Hepatic VOD | 1 | 1 | 0.706 |
Myocarditis | 0 | 0 | > 0.999 |
Seizure | 2 | 0 | 0.477 |
Treatment-related mortality | 0 | 0 | > 0.999 |
Values are presented as median (range) or number. HDCT/auto-SCT, high-dose chemotherapy and autologous stem cell transplantation; ANC, absolute neutrophil count; PLT, platelet; BT, body temperature; VOD, veno-occlusive disease.
The first of 3 consecutive days that ANC exceeded 500/mm3,
The first of 7 consecutive days that PLT count exceeded 20,000/mm3 without transfusion.