Table 2.
Multivariate Cox-regression model
| Variable | RFS |
DRFS |
OS |
BCSS |
||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age ≥ 65 yr | 1.68 (1.11-2.55) | 0.015 | 2.48 (1.09-2.86) | 0.022 | 1.91 (1.09-3.36) | 0.024 | 1.73 (0.94-3.21) | 0.077 |
| TNM staging | 4.31 (1.66-2.72) | < 0.001 | 6.59 (1.95-3.54) | < 0.001 | 3.17 (2.19-4.56) | < 0.001 | 3.83 (2.54-5.77) | < 0.001 |
| Lymphovascular invasion | 1.98 (1.41-2.77) | < 0.001 | 2.48 (1.66-3.68) | < 0.001 | 1.86 (1.14-3.03) | 0.013 | 2.15 (1.27-3.63) | 0.005 |
| Adjuvant chemotherapy | 0.62 (0.39-0.92) | 0.018 | 0.75 (0.43-1.25) | 0.299 | 0.52 (0.28-0.96) | 0.035 | 0.55 (0.28-1.07) | 0.082 |
| Adjuvant radiotherapy | 0.79 (0.58-1.16) | 0.260 | 0.69 (0.47-1.08) | 0.098 | 0.85 (0.49-1.45) | 0.555 | 0.73 (0.41-1.31) | 0.296 |
| Adjuvant endocrine therapy | 0.47 (0.34-0.65) | < 0.001 | 0.42 (0.29-0.60) | < 0.001 | 0.19 (0.12-0.31) | < 0.001 | 0.19 (0.12-0.31) | < 0.001 |
RFS, recurrence-free survival; DRFS, distant recurrence-free survival; OS, overall survival; BCSS, breast cancer–specific survival; HR, hazard ratio; CI, confidence interval.