Table 3.
Random Forest classification of TG-GATE data according to dose level
| Low dose | Medium dose | High dose | ||||
|---|---|---|---|---|---|---|
|
|
|
|
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| Samples | Conc. (mg/mL) | Predicted class | Conc. (mg/mL) | Predicted class | Conc. (mg/mL) | Predicted class |
| NGTXC | ||||||
| Acetamide | 300 | 0(*) | 1000 | 0(*) | 200 | 0(*) |
| Carbamazepine | 30 | 0(*) | 100 | 0(*) | 300 | NGTX |
| Carbon tetrachloride | 30 | 0(*) | 100 | 0(*) | 300 | 0(*) |
| Clofibrate | 30 | 0(*) | 100 | 0(*) | 300 | NGTX |
| Ethinylestradiol | 1 | 0(*) | 3 | NGTX | 10 | NGTX |
| Fenofibrate | 10 | 0(*) | 100 | NGTX | 100 | NGTX |
| Gemfibrozil | 30 | NGTX | 100 | NGTX | 300 | NGTX |
| Methapyrilene | 10 | 0(*) | 30 | 0(*) | 100 | 0(*) |
| Methyltestosterone | 30 | 0(*) | 100 | 0(*) | 300 | 0(*) |
| Monocrotaline | 3 | 0(*) | 10 | 0(*) | 30 | 0(*) |
| Phenobarbital | 10 | 0(*) | 30 | 0(*) | 100 | NGTX |
| Thioacetamide | 4.5 | 0(*) | 15 | NGTX | 45 | NGTX |
| WY-14643 | 10 | NGTX | 30 | NGTX | 100 | NGTX |
|
| ||||||
| GTX | ||||||
| Acetamidofluorene | 30 | 0 | 100 | 0 | 300 | 0 |
| Carboplatin | 1 | 0 | 3 | 0 | 10 | 0 |
| Colchicine | 0.5 | 0 | 1.5 | 0 | 5 | 0 |
| Doxorubicin | 0.1 | 0 | 0.3 | 0 | 1 | 0 |
| Lomustine | 0.6 | 0 | 2 | 0 | 6 | 0 |
| Naphthyl isothiocyanate | 1.5 | 0 | 5 | 0 | 15 | 0 |
| Tamoxifen | 6 | 0 | 20 | 0 | 60 | 0 |
|
| ||||||
| Non-Hepatocarcinogen | ||||||
| Acetaminophen | 300 | 0 | 600 | 0 | 1000 | 0 |
| Allyl alcohol | 3 | 0 | 10 | 0 | 30 | 0 |
| Amiodarone | 20 | 0 | 60 | 0 | 200 | 0 |
| Aspirin | 45 | 0 | 150 | 0 | 450 | 0 |
| Caffeine | 10 | 0 | 30 | 0 | 100 | 0 |
| Diclofenac | 1 | 0 | 3 | 0 | 10 | 0 |
| Erythromycin ethylsuccinate | 100 | 0 | 300 | 0 | 1000 | 0 |
| Ethanol | 400 | 0 | 1200 | 0 | 4000 | 0 |
| Gentamicin | 10 | 0 | 30 | 0 | 100 | 0 |
| Nimesulide | 10 | 0 | 30 | 0 | 100 | 0 |
| Promethazine | 20 | 0 | 60 | 0 | 200 | 0 |
| Tannic acid | 100 | 0 | 300 | 0 | 1000 | 0 |
| Tetracycline | 100 | 0 | 300 | 0 | 1000 | 0 |
*
Misclassified.