Table 2. Neuroimaging studies of single-dose oxytocin administration for individuals with ASD.
| Study | ASD Participants | Dosage | Task | |||||
|---|---|---|---|---|---|---|---|---|
| N | Age | Gender | IQ | Amount | Procedure | |||
| fMRI | ||||||||
| Social Communicative Function | ||||||||
| Domes et al., 2013a | [42] | 14 | 24 | 14M | 112 | 24IU | Intranasal spray | Face- and house- matching task |
| Domes et al., 2013b | [43] | 14 | 24 | 14M | 112 | 24IU | Intranasal spray | Facial emotion recognition task of eye or mouth |
| Gordon et al., 2013 | [44] | 21 | 13.2 (8-16) |
18boys 3girls | 18 or 24 IU | Intranasal spray | Emotion judgement (RMET) Category of automobile judgement |
|
| Watanabe et al., 2014 | [46] | 33 | 28.5 | 33M | >80 | 24IU | Intranasal spray | Judgement of friend or foe based on speeach and facial expression |
| Aoki et al., 2014a | [40] | 20 | 30.8 (22-41) | 20M | 109 | 24IU | Intranasal spray | Emotion and belief understanding by catoorn |
| Restricted and Repetitive Patterns | ||||||||
| No study | ||||||||
| Comorbidity | ||||||||
| No study | ||||||||
| MRS | ||||||||
| Social Communicative Function | ||||||||
| Aoki et al., 2014b | [39] | 40 | 30 | 40M | >80 | 24IU | Intranasal spray | |
| Restricted and Repetitive Patterns | ||||||||
| No study | ||||||||
| Comorbidity | ||||||||
| No study | ||||||||
Amount, dosage amount per single administration; gender, participants’ gender; age, range of participant age; N, number of participants; M, males; F, Females; RMET, Reading the Mind in the Eyes Test.