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. Author manuscript; available in PMC: 2016 Oct 26.
Published in final edited form as: Anal Chem. 2016 Feb 5;88(4):2392–2398. doi: 10.1021/acs.analchem.5b04409

Figure 4.

Figure 4

Tissue sections (12 μm thick) from a liver dosed in vivo. (A) One section was quantitatively imaged at a spatial resolution of 350 μm and shows little to no RIF detected in the blood vessels outlined with a black dotted line. A concentration gradient of RIF was also detected around the portal tracts (low to high), revealing the microphysiology of the drug within the liver. (B) A serial section was stained with hematoxylin and eosin for visualization of the blood vessels. (C) The MALDI IMS data and HPLC-MS/MS data are in agreement with 90.4% similarity.