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. Author manuscript; available in PMC: 2016 Oct 26.
Published in final edited form as: Nat Commun. 2015 Feb 17;6:6204. doi: 10.1038/ncomms7204

Figure 3. Disrupting the function of the PHD1 abrogates the catalytic activity of KDM5A.

Figure 3

(a) Binding of WT KDM5A1–797 and W335A KDM5A1–797 to H3K4me0 tail peptides. (b) Stimulation of H3K4me3 demethylation by WT and W335A KDM5A1–797 with increasing concentration of H3K4me0 effector tail peptides. (c) Demethylation activity of WT KDM5A1–797 and W335A KDM5A1–797 towards H3K4me3 histone tails. Errors (n ≥ 3) represent s.e.m.