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. Author manuscript; available in PMC: 2016 Oct 26.
Published in final edited form as: Cancer Res. 2012 Jan 26;72(6):1529–1537. doi: 10.1158/0008-5472.CAN-11-2602

Figure 6.

Figure 6

PTP1B down-regulation impedes cell migration in vitro. (A and B) (A) LNCaP and (B) C4-2 cells transiently transfected with an siRNA against PTP1B (si1B) or a non-targeting sequence (siSC) were androgen-deprived for 48hrs. Cells were then treated with R1881 or the vehicle for 36hrs before FBS-induced cell migration as described in Materials and Methods. (C) DU145 cells were transiently transfected with si1B or siSC for 72hrs before FBS-induced cell migration (Mann-Whitney test; * p<0.05, ** p<0.01 compared to the corresponding siSC; N=3 +/− SEM).