TABLE V.
Prevalence of BRCA1/2 mutations by PTEN (phosphate and tensin homologue) status in patients with triple-negative breast cancer (TNBC)
| PTEN status | BRCA status [n (%)] | p Value for … | |||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| All | BRCA1 | BRCA2 | Non-BRCA | BRCA1/2 | BRCA1 | BRCA2 | |
| All with TNBC | 68 | 15 (22.1) | 6 (14.7) | 47 (69.1) | 0.822 | 0.495 | 0.684 |
| Loss | 37 | 7 (18.9) | 4 (10.8) | 26 (70.3) | |||
| Intact | 31 | 8 (25.8) | 2 (6.5) | 21 (67.7) | |||
| With family history | 34 | 10 (29.4) | 5 (14.7) | 19 (55.9) | 0.730 | 1.000 | 1.000 |
| Loss | 17 | 5 (29.4) | 3 (17.6) | 9 (53.0) | |||
| Intact | 17 | 5 (29.4) | 2 (11.8) | 10 (58.8) | |||
| Without family history | 34 | 5 (14.7) | 1 (2.9) | 28 (82.4) | 0.672 | 0.627 | 1.000 |
| Loss | 20 | 2 (10.0) | 1 (5.0) | 17 (85.0) | |||
| Intact | 14 | 3 (21.4) | 0 (0.0) | 11 (78.6) | |||
Pts = patients.