. 2016 Apr 28;37(39):2993–2997. doi: 10.1093/eurheartj/ehw156

Table 1.

Blood leukocyte patterns in PHD1^−/−LDLR^−/− mice and controls on a western-type diet (n=10 per genotype)

Blood parameter	LDLR^−/− (mean ± D)	PHD1^−/−LDLR^−/− (mean ± SD)	P-value
CD45⁺ leucocytes (counts/µL)^a	2954 ± 829.9	1792 ± 627.1	0.0014*
CD3⁺ T cells (counts/µL)^a	283.5 ± 69.17	213.7 ± 73.93	0.0553
CD4⁺ T cells (counts/µL)^a	162.3 ± 43.91	124.6 ± 40.90	0.1088
CD8a⁺ T cells (counts/µL)^a	106.4 ± 22.81	78.06 ± 29.77	0.033*
NK-T cells (counts/µL)^a	34.33 ± 16.43	11.91 ± 9.144	0.0012*
NK cells (counts/µL)^a	98.66 ± 24.28	46.15 ± 13.12	0.0001*
B220⁺ B cells (counts/µL)^a	749.6 ± 279.8	522.1 ± 261.5	0.0702
Ly6C^high monocytes (counts/µL)^a	180.5 ± 104.2	68.23 ± 67.18	0.025*
Ly6C^int monocytes (counts/µL)^a	17.37 ± 5.370	10.17 ± 6.826	0.0418*
Ly6C^low monocytes (counts/µL)^a	65.89 ± 16.51	55.21 ± 29.18	0.1416
Ly6C^high/Ly6C^low ratio^a	2.48 ± 1.166	1.067 ± 0.7174	0.0164*
Red Blood cells (·10¹²/L)^a	9.036 ± 1.097	8.610 ± 1.404	0.1027
Haematocrit (L/L)	0.4149 ± 0.03968	0.4418 ± 0.03707	0.1104
Haemoglobin (mmol/L)^a	8.400 ± 0.8230	8.844 ± 0.8110	0.1326
Platelets (·10⁹/L)^a	823.1 ± 69.29	817.8 ± 239.7	0.937

All data were tested for normal distribution using Shapiro-Wilk normality test. Variables indicated with the letter ‘a’ did not pass normality test and were subsequently analysed using Mann–Whitney rank-sum test. All other variables were tested with the Student's t-test. * indicates p-value <0.05.