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. 2016 Mar 22;25(11):2349–2359. doi: 10.1093/hmg/ddw087

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Regional plot of association results and recombination rates for the 2q35 locus. In the panel, −log₁₀ P values (y-axis) of the SNPs are shown according to their chromosomal positions (x-axis). The top SNP is shown as a large triangle and is labelled by its rsID. The colour intensity of each symbol reflects the extent of LD with the top SNP: white (r²= 0) through to dark red (r²= 1.0), with r² estimated from the 1000 Genomes Phase 1 data. Genetic recombination rates (cM/Mb) are shown with a light blue line. Physical positions are based on NCBI build 37 of the human genome. Also shown are the relative positions of genes and transcripts mapping to each region of association. The lower panel shows the chromatin state segmentation track (ChromHMM) in HCT116 CRC and GM12878 lymphoblastoid cell lines.