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. 2016 Mar 22;25(11):2208–2219. doi: 10.1093/hmg/ddw089

Figure 1.

Figure 1.

Expression of TET2 and global 5hmC levels were decreased in the umbilical veins of GDM and preeclampsia. (A) Specific decrease of TET2 expression in both GDM and preeclampsia. qRT-PCR indicated a specific and significant decrease of TET2 expression in both GDM and preeclampsia. t-test P-values are indicated. C, control; G, GDM; P; preeclampsia. (B) Global reduction of 5hmC levels in GDM and preeclampsia. Genome-wide normalized 5hmC mapped reads were counted in each 10 kb binned human genome between the two diseases versus their controls. Bins containing less 5hmC reads in each diseases than that of controls are shown in red, whereas bins in blue indicated the opposite. The number of bins is indicated. Bins containing more than 10 5hmC reads are shown.