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. 2016 Mar 22;25(11):2208–2219. doi: 10.1093/hmg/ddw089

Figure 5.

Figure 5.

Aberrant 5hmC distributions in GDM and preeclampsia resulted in the alteration of transposon and repetitive element expression. (A) Aberrant 5hmC distributions in GDM and preeclampsia were observed on several repetitive elements in human genome. Unique mapped reads were aligned to the RepeatMasker track of NCBI37v1/mm9 using Bowtie—q—best parameters, allowing no more than two mismatches across the entire 38 bp read. Aligned reads were assigned to repeat class annotations defined by RepeatMasker. 5hmC reads were counted in each repetitive class, and then divided by total aligned reads by Bowtie to achieve their percentage. (B) The expression of LINE and Alu decreased in GDM and preeclampsia. qRT-PCR were performed to determine the expression of LINE and Alu in GDM and preeclampsia compared to controls. t-test P-values were indicated.