Table 4A.

Sensitivity, Specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) for Definite Detection of Fungi on IVCM Compared with Culture or Light Microscopy

Grader	N∗	TP	TN	FP	FN	Sensitivity (%, 95% CI)	Specificity (%, 95% CI)	PPV (%, 95% CI)	NPV (%, 95% CI)
1	219	139	49	9	22	86.3 (80–91.2)	84.5 (72.6–92.7)	93.9 (88.8–97.2)	69.0 (56.9–79.5)
2	217	121	55	9	32	79.1 (71.8–85.2)	85.9 (75.0–93.4)	93.1 (87.3–96.8)	63.2 (52.2–73.3)
3	190	117	44	9	20	85.4 (78.4–90.8)	83.0 (70.2–91.9)	92.9 (86.9–96.7)	68.8 (55.9–79.8)
4	224	145	42	15	22	86.8 (80.7–91.6)	73.7 (60.3–84.5)	90.6 (85.0–94.7)	65.6 (52.7–77.1)
5†	239	158	50	13	18	89.8 (84.3–93.8)	79.4 (67.3–88.5)	92.4 (87.4–95.9)	73.5 (61.4–83.5)

FN = false-negative; FP = false-positive; TN = true-negative; TP = true-positive.

^∗The total no. of patients classified as having possible fungus by each grader and therefore excluded from this analysis are as follows: grader 1 (n = 21), grader 2 (n = 23), grader 3 (n = 49), grader 4 (n = 16), grader 5 (n = 1).

^†Grader 5 was unmasked to ulcer clinical features.