Fig. 1.

Effect of 18B12 treatment on histological alterations and behavioral disturbance after spinal cord injury (SCI). An important injury to the spinal cord was observed in (b) SCI mice compared with (a) sham and (c) 18B12-treated mice. The severity of tissue damage was enhanced in tissue sections obtained from (b) injured mice and from (c) 18B12-treated mice. (d) Histological score was prepared by an independent observer. (e) The motor function of mice subjected to trauma was evaluated up to 6 weeks after damage. Recovery from motor disturbance was graded using the Basso Mouse Scale. Each data are expressed as mean ± SEM of 10 mice for each group. ***p < 0.001 vs sham; ^### p < 0.001 vs SCI. (a, b) Hematoxylin and eosin ND = not detectable