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Schematic illustrating the production of stalled replication fork which can form γH2AX foci. A replication fork is formed during DNA replication, the two original stands branch forming single strands and serve as templates for synthesis of the complimentary strand which is synthesized in the 5′ to 3′ direction. The presence of a lesion, such as a SSB, can result in the replication fork stalling which can result in γH2AX foci.
