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miR-30b directly targets the SCN9A 3′UTR. (a) Sequence alignment of miR-30b and the human and rat SCN9A 3′UTR. The predicted sequences for the pairing of the SCN9A 3′UTR and miR-30b are indicated by red letters. (b) Luciferase activity of luciferase reporter genes bearing SCN9A 3′UTR segments or a mutated (Mut) 3′UTR in HEK293 cells. The data are the mean ± SEM. *indicates P < 0.05 compared with scramble miRNA. # indicates P < 0.05 compared with the miR-30b agomir.
