Figure 4. Integrated immune perception at the scale of SLOs.

The interaction between APCs and epitope-specific T-cells occur in a multitude of niches that provide distinct combinations of output signals from primary perception tasks. In each niche, these output signals are integrated at the single cell level by epitope-specific T-cells. This step results in the generation of a large array of TH or CD8 T-cell subsets that possibly include anergic T-cells. Eventually, the integrated perception of IOs is performed at the scale of SLOs by a large variety of antigen-specific T-cell and B-cell clones. Only TH-cell clones are depicted in the diagram.