Table 2. Identification of proteins from spots with increased abundance that contributed to the separation of kidney proteome profiles of mature offspring previously exposed to cigarette smoke throughout development (GD1-PD21) [PLS-DA model, VIP values (≥1.75)].
VIP (Variable Importance in Projection); GI Number (NCBI protein sequence GenInfo Identifier ). Corresponds to Figure 1.
| Spot | GI Number | Abbreviation 1 | Name | VIP | Percent Change |
|---|---|---|---|---|---|
| 4 | 163310765 | ALB* | albumin | 1.96 | 64 |
| 5 | No ID | 2.14 | 101 | ||
| 6 | No ID | 1.65 | 13 | ||
| 8 | 6425087 | ACTG1 | gamma actin-like protein | 1.89 | 12 |
| 9 | 14548301 | cytochrome b-c1 complex subunit 1, mitochondrial | 1.43 | 9 | |
| 10 | No ID | 1.72 | 19 | ||
| 16 | No ID | 1.46 | 31 | ||
| 17 | 19527258 | aldehyde dehydrogenase family 6, subfamily A1 | 1.8 | 36 | |
| 18 | 78099319 6753036 |
aldehyde dehydrogenase family 9 member A1 mitochondrial aldehyde dehydrogenase 2 |
1.33 | 31 | |
| 20 | 148677501 | ATP5A1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, isoform CRA_e | 1.58 | 126 |
| 21 | No ID | 1.78 | 65 | ||
| 22 | No ID | 1.66 | 173 | ||
| 23 | 12003362 22267442 6996911 |
IDH2 | NADP+-specific isocitrate dehydrogenase ubiquinol cytochrome c reductase core protein 2 argininosuccinate synthetase 1 |
1.66 | 105 |
| 25 | 21450129 | ACAT1 | acetyl-Coenzyme A acetyltransferase 1 precursor | 1.51 | 19 |
| 26 | 6754036 | GOT2 | glutamate oxaloacetate transaminase 2, mitochondrial | 1.48 | 37 |
| 28 | 9789985 21450129 |
isovaleryl coenzyme A dehydrogenase acetyl-Coenzyme A acetyltransferase 1 precursor |
1.87 | 18 | |
| 29 | 22128627 | sorbitol dehydrogenase | 2.11 | 28 | |
| 31 | No ID | 1.60 | 16 | ||
| 32 | No ID | 1.79 | 42 | ||
| 33 | 11132435 | galactose kinase | 1.41 | 20 | |
| 34 | No ID | 1.57 | 20 | ||
| 35 | 31982300 | hemoglobin, beta adult major chain | 1.27 | 110 | |
| 36 | 6753060 155369696 |
ANXA5 | annexin A5 hypothetical protein LOC683313 | 1.51 | 19 |
| 37 | 31982632 | ATP5B | aspartoacylase 3 | 1.75 | 24 |
| 1374715 | ATP synthase beta subunit | ||||
| 38 | 19525729 11560131 |
crystallin, lambda 1 dimethylarginine dimethylaminohydrolase 1 |
1.51 | 10 | |
| 39 | 9506589 | FBP1 | fructose-1,6-bisphosphatase 1 | 1.47 | 12 |
| 44 | 31982186 6679937 |
MDH2 | malate dehydrogenase 2, NAD (mitochondrial) glyceraldehyde-3-phosphate dehydrogenase |
1.61 | 73 |
| 48 | 6755963 13385680 |
VDAC1 | voltage-dependent anion channel 1 2,4-dienoyl CoA reductase 1 | 2.14 | 80 |
| 54 | 31982229 | ketohexokinase | 1.44 | 12 | |
| 55 | 6680019 | GCLM | glutamate-cysteine ligase, modifier subunit | 2.06 | 20 |
| 56 | 15617203 | chloride intracellular channel 1 | 2.07 | 22 | |
| 57 | 1374715 | ATP5B | ATP synthase beta subunit | 1.51 | 21 |
| 60 | No ID | 1.31 | 33 | ||
| 62 | No ID | 1.62 | 23 | ||
| 63 | 2673845 17389257 6754976 |
GPX1 | glutathione peroxidase cytidine monophosphate (UMP-CMP) kinase 1 peroxiredoxin 1 |
1.68 | 17 |
1
Denotes abbreviation used in Figure 6.