Experiment 1: Ischemic lesion of motor cortex impairs multiple measures of task performance. (A) Peak turn angle and (B) success rate of animals in Cohort A was significantly reduced compared to pre-lesion at all time points following lesion. (C) Number of trials performed per day showed a transient reduction during Post, but returned to pre-lesion levels during Weeks 1-4. (D) The maximum turn velocity, calculated as the maximum of the derivative of the turn angle, exhibited a transient reduction following injury but did not reach significance at Week 4. All plots show group averages (N=7) in black lines and light gray lines represent individual animals. Error bars indicate SEM. Significant differences were determined by paired t-tests and are noted as *p<0.05, **p<0.01, ***p<0.001.