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. 2016 Oct 26;12(10):e1005984. doi: 10.1371/journal.ppat.1005984

Fig 2. Effect of Slc7a2 deletion on C. rodentium colitis.

Fig 2

C57BL/6 or Slc7a2 –/–mice were infected with C. rodentium (C. rod). (A) Survival was monitored daily; the Kaplan–Meier plot was performed from 5 separate experiments (n = 33 WT and n = 30 Slc7a2 –/–mice); no death was observed in uninfected animals. (B) Body weights of all the animals in Panel (A) were measured daily and are presented as percentage of initial body weight. *P < 0.05, **P < 0.01, ***P < 0.001 compared to uninfected animals with the same genotype. (C) After euthanasia, colons were harvested, washed, and weighed. Values are expressed as percent of body weight on the day of sacrifice. (D-E) Colons were Swiss-rolled and stained with H&E (D) and scored for histologic injury (E); Scale Bar, 100 μm. For C and E, *P < 0.05, **P < 0.01, ***P < 0.001; the data depicted for Day 14 are from the same mice presented in (A) and the data at Day 7 is derived from a separate experiment.