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ChIP assay was performed using antibodies against HIF-α or IgG to confirm the binding of HIF-1 α on the putative HREs in the promoters of specific HRMs. qPCR data showing fold enrichment of bound chromatin compared with input in hMSCs grown in (a) hypoxic or (c) normoxic conditions and hESCs in (b) hypoxic and (d) normoxic conditions. (e) Putative hypoxia signal transduction feedback loop in hESC and hMSCs.
