Table 1.
Baseline Demographic, Biochemical, and Histologic Characteristics of Subjects
| Sitagliptin (n=25) | Placebo (n=25) | P-Value | |
|---|---|---|---|
| Demographics | |||
| Age (years) | 52.9 ± 11.9 | 54.9 ± 11.3 | .5358 |
| Female patients | 12 (48%) | 17 (68%) | .1520 |
| Weight (kg) | 92.8 ± 18.7 | 86.3 ± 20.6 | .2483 |
| BMI (kg/m2) | 31.9 ± 5.4 | 31.7 ± 4.7 | .8614 |
| Non-Hispanic Whites | 6 (24%) | 10 (40%) | .3582 |
| Hispanics | 9 (36%) | 9 (36%) | 1.000 |
| Diabetes | 12 (48%) | 13 (52%) | .7773 |
| Biochemical profile | |||
| ALT (IU/L) | 43.0 (26.0) | 40.0 (26.0) | .5437 |
| AST (IU/L) | 28.0 (15.0) | 29.0 (19.0) | .4877 |
| AST:ALT | 0.7 (0.3) | 0.8 (0.4) | .3713 |
| Alk Phos (U/L) | 73.0 (29.0) | 79.0 (18.0) | .3271 |
| GGT (U/L) | 34.0 (38.0) | 32.0 (36.0) | .7958 |
| Total bilirubin (mg/dL) | 0.4 (0.1) | 0.5 (0.4) | .5921 |
| Glucose (mg/dL) | 104.0 (27.0) | 106.0 (38.5) | .6690 |
| Insulin (μU/mL) | 21.0 (14.0) | 23.0 (8.5) | .8904 |
| Hgb A1C (%) | 6.1 (0.5) | 6.2 (0.8) | .6765 |
| FFA (mmol/L) | 0.5 (0.4) | 0.5 (0.3) | .5211 |
| HOMA-IR | 5.9 (4.8) | 5.4 (3.0) | .4993 |
| Triglycerides (mg/dL) | 185.0 (52.0) | 150.0 (96.0) | .4276 |
| Total cholesterol (mg/dL) | 191.0 (48.0) | 188.0 (49.0) | .8113 |
| LDL (mg/dL) | 100.0 (42.0) | 89.5 (46.0) | .4851 |
Mean ± standard deviation is presented above for normally distributed variables with associated p-values from t-test, Median (interquartile range) for non-normally distributed variables with associated p-values from Wilcoxon-Mann-Whitney performed and chi-square or Fisher's exact test on all categorical variables.
BMI, Body Mass Index; AST, Aspartate Aminotransferase; ALT, Alanine Aminotransferase; Hgb A1C, hemoglobin A1C; LDL, Low-Density Lipoprotein; FFA, Free Fatty Acids; Alk Phos, Alkaline Phosphatase; GGT, Gamma-Glutamyl Transferase; HOMA-IR, homeostatic model assessment of insulin resistance.