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Silencing of HMGB3 expression inhibited cell proliferation. RNA interference was used to knockdown HMGB3 in the MGC803 cells (A) and BGC823 cells (B). The expression of HMGB3 in the blank, siR-NC, and siR-HMGB3 group cells were detected by Western blot assay. (C, D) Cellular proliferation ability was assayed by MTT assay. * p<0.05, ** p<0.01, and *** p<0.001 vs. siR-NC group. Blank – non-transfected; siR-NC – control siRNA; siR-HMGB3 – HMGB3 siRNA; HMGB3 – high mobility group-box 3.
