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HMGB3 downregulation inhibited invasion of GC cells. A transwell assay was performed to examine the invasion capacity of MGC803 cells (A) and BGC823 cells (B) after transfection with siR-HMGB3 or siR-NC. The changes of MMP2 and MMP9 protein levels were assessed by Western blot assays (C, D). * p<0.05 and ** p<0.01 vs. siR-NC group. Blank – non-transfected; siR-NC – control siRNA; siR-HMGB3 – HMGB3 siRNA; HMGB3 – high mobility group-box 3.
