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. 2016 Oct 22;22:3894–3901. doi: 10.12659/MSM.897580

Figure 4.

Figure 4

MiR-16 alleviates inflammatory pain by inhibition of p38 MAPK. (A) Relative p-p38 expression level after infection of CFA; (B) Mechanical withdrawal threshold after injection; (C) Thermal withdrawal latencies after injection; (D) Frequency responses to cold stimulation after injection. MiR – microRNA; CFA – complete Freund’s adjuvant; MAPK – mitogen-activated protein kinase; p-p38 – phosphorylation of p38; * P<0.05 compared to control group; ** P<0.01 compared to 0 h after injection or control group; # P<0.05 compared to CFA group; & P<0.05 compared to CFA + miR-16 group.