Table 4.
PLA Scaffolds for Cutaneous Tissue Engineering.
| Scaffold type | Application | Reference |
|---|---|---|
| Drug-loaded electrospun nanofibrous PLLA mesh | In vitro drug delivery of wound-healing agents alkannin and shikonin | [68] |
| Drug-loaded electrospun nanofibrous PLA patch | In vitro cytotoxicity of wound-healing agent curcumin on mouse myoblasts; in vivo implantation in a full thickness skin defect in mice | [69] |
| Drug-loaded electrospun nanofibrous PLA scaffold | In vitro cytotoxicity test of ibuprofen on human dermal keratinocytes and fibroblasts; in vivo implantation in a full thickness mouse skin incision model | [70] |
| Electrospun nanofibrous PLA scaffold coated with plasmid/poly(ethylenimine) | In vitro plasmid deliver and transfection of 3T3 cells; in vivo wound healing repair in a mouse dorsal full thickness defect | [77] |
| Drug-loaded uniaxial PLA, uniaxial collagen, and coaxial collagen core/PLA sheath electrospun nanofiber wound dressing | In vitro release of gentamicin, susceptibility testing against pathogenic bacteria, and culture with MG-63 osteoblasts | [31] |
| Drug-loaded PLA/PEO blend nanofibrous wound dressing | In vitro release of antimicrobial peptide bacteriocin and susceptibility testing against pathogenic bacteria | [74] |
| Drug-loaded PLA/PEO blend nanofibrous wound dressing | In vitro testing of antimicrobial peptide nisin against S. aureus and in vivo evaluation of nanofibrous wound dressing in an infected full-thickness murine cutaneous wound | [75] |
| Electrospun nanofibrous PLA wound dressing doped with silver nano/microparticles | In vitro drug delivery of silver in human dermal keratinocyte culture and antimicrobial effect on S. aureus | [76] |
| Drug-loaded electrospun PLA nano/microfiber wound dressing | In vivo delivery of anti-scarring agent 20(R)-ginsenoside Rg3 in a rabbit ear model of hypertrophic scarring | [78] |