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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Exp Eye Res. 2016 Apr 26;158:85–93. doi: 10.1016/j.exer.2016.04.020

Figure 3. Immunohistochemical localization of KATP channel subunits in tissues of the conventional outflow pathway.

Figure 3

(A–E) In normal human trabecular meshwork tissue, SUR2B, Kir6.1 and Kir6.2 were present while SUR1 and SUR2A were absent. (F–J) In mouse eyes, results similar to human studies were obtained – SUR2B, Kir6.1 and Kir6.2 were present while SUR1 and SUR2A were absent. Some auto-fluorescence was observed with SUR1 and SUR2A antibodies but the overall intensity was much lower than the subunits that stained positive. SUR2B, Kir6.1 and Kir6.2 were evenly distributed in the trabecular meshwork (TM), ciliary body (CB), iris (I) and inner and outer wall of Schlemm’s canal (SC). AC, anterior chamber. Figure reproduced from images published in Chowdhury et al., 2011 and Chowdhury et al., 2013.